Search results for "Brain water"

showing 2 items of 2 documents

Introducing the concept of “CSF-shift edema” in traumatic brain injury

2018

Brain edema after severe traumatic brain injury (TBI) plays an important role in the outcome and survival of injured patients. It is also one of the main targets in the therapeutic approach in the current clinical practice. To date, the pathophysiology of traumatic brain swelling is complex and, being that it is thought to be mainly cytotoxic and vasogenic in origin, not yet entirely understood. However, based on new understandings of the hydrodynamic aspects of cerebrospinal fluid (CSF), an additional mechanism of brain swelling can be considered. An increase in pressure into the subarachnoid space, secondary to traumatic subarachnoid hemorrhage, would result in a rapid shift of CSF from t…

0301 basic medicinePathologymedicine.medical_specialtySubarachnoid hemorrhageTraumatic brain injurybrain edema; cisternostomy; decompressive hemicraniectomy; paravascular pathway; traumatic brain injury; Cellular and Molecular NeuroscienceBrain water03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineCerebrospinal fluidEdemaBrain Injuries TraumaticmedicineHumansparavascular pathwaybrain edemaBrain edemabusiness.industrytraumatic brain injurymedicine.diseasecisternostomyPathophysiology030104 developmental biologymedicine.anatomical_structureSubarachnoid spacemedicine.symptomExtracellular Spacebusinessdecompressive hemicraniectomybrain edema; cisternostomy; decompressive hemicraniectomy; paravascular pathway; traumatic brain injury030217 neurology & neurosurgeryJournal of Neuroscience Research
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Comparison of speed-vacuum method and heat-drying method to measure brain water content of small brain samples

2016

Abstract Background A reliable measurement of brain water content (wet-to-dry ratio) is an important prerequisite for conducting research on mechanisms of brain edema formation. The conventionally used oven-drying method suffers from several limitations, especially in small samples. A technically demanding and time-consuming alternative is freeze-drying. New method Centrifugal vacuum concentrators (e.g. SpeedVac/speed-vacuum drying) are a combination of vacuum-drying and centrifugation, used to reduce the boiling temperature. These concentrators have the key advantages of improving the freeze-drying speed and maintaining the integrity of dried samples, thus, allowing e.g. DNA analyses. In t…

Male0301 basic medicineHot TemperatureTime FactorsGenotyping TechniquesVacuumNeuroscience(all)Analytical chemistrySmall brainBrain EdemaCentrifugationBrain water03 medical and health sciences0302 clinical medicineBrain Injuries TraumaticAnimalsDesiccationWater contentBrain ChemistryMoistureChemistryBrain edemaGeneral Neurosciencetechnology industry and agricultureArea under the curveWaterMice Inbred C57BLDisease Models AnimalBoiling pointNeuroprotective AgentsSodium Bicarbonate030104 developmental biologyROC CurveArea Under CurveContent (measure theory)Feasibility Studies030217 neurology & neurosurgeryBiomedical engineeringJournal of Neuroscience Methods
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